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把握机遇，引领未来丨大连市领导接见宝藤等智能医疗大数据云团队
2018年5月5日下午，大连市谭成旭市长、靳国卫副市长及各委办局、高新区领导在市政府亲切接见了智能医疗大数据云团队，听取项目进展汇报并勉励团队抓住机遇加快推进项目实施！
宝藤精彩亮相第六届上交会，引领智能医疗大数据时代.
4月19日，由商务部、科技部、国家知识产权局和上海市人民政府主办的第六届中国（上海）国际技术进出口交易会（简称“上交会”）在上海世博展览馆正式拉开序幕。上海宝藤以“智能医疗大数据”为主题精彩亮相，展示了近年来宝藤在精准医学及智能医疗大数据领域取得的创新成果，引发广泛关注。
澳大利亚维州政府及医药产业代表团莅临宝藤考察
3月14日，澳大利亚维多利亚州政府及医药产业代表团一行莅临上海张江考察洽谈合作。宝藤生物作为张江高科技园区精准医学大数据示范性企业，成为代表团行程中的重要一站。
上海市人大代表视察宝藤，洞见智慧医疗产业的未来
1月10日，上海市人大代表及在沪全国人大代表一行230余人，在上海市人大常委会吴汉民副主任带领下，莅临上海张江宝藤生物总部，就张江科技创新法制保障专题开展集中视察。
President New Year Message
As the new year begins, everything looks fresh! During the hard work, we have said goodbye to 2017 and welcome a hopeful 2018!
Secretary of Municipal Party Committee of Baiyin investigated Shanghai Biotecan Pharmaceuticals Corporation
Zhiquan Zhang,secretary of the municipal party committee of Baiyin City, Gansu Province, visited Biotecan headquarters to talk on investment, accompanied by Baiyin municipal government, Baiyin High-tech Zone Administrative Committee, Innovation Office and other departmental leaders. Dr. Lou, chairman of the Biotecan had a well-talk with them ...
把握机遇，引领未来丨大连市领导接见宝藤等智能医疗大数据云团队
2018年5月5日下午，大连市谭成旭市长、靳国卫副市长及各委办局、高新区领导在市政府亲切接见了智能医疗大数据云团队，听取项目进展汇报并勉励团队抓住机遇加快推进项目实施！
宝藤精彩亮相第六届上交会，引领智能医疗大数据时代.
4月19日，由商务部、科技部、国家知识产权局和上海市人民政府主办的第六届中国（上海）国际技术进出口交易会（简称“上交会”）在上海世博展览馆正式拉开序幕。上海宝藤以“智能医疗大数据”为主题精彩亮相，展示了近年来宝藤在精准医学及智能医疗大数据领域取得的创新成果，引发广泛关注。
澳大利亚维州政府及医药产业代表团莅临宝藤考察
3月14日，澳大利亚维多利亚州政府及医药产业代表团一行莅临上海张江考察洽谈合作。宝藤生物作为张江高科技园区精准医学大数据示范性企业，成为代表团行程中的重要一站。
上海市人大代表视察宝藤，洞见智慧医疗产业的未来
1月10日，上海市人大代表及在沪全国人大代表一行230余人，在上海市人大常委会吴汉民副主任带领下，莅临上海张江宝藤生物总部，就张江科技创新法制保障专题开展集中视察。
President New Year Message
As the new year begins, everything looks fresh! During the hard work, we have said goodbye to 2017 and welcome a hopeful 2018!
Secretary of Municipal Party Committee of Baiyin investigated Shanghai Biotecan Pharmaceuticals Corporation
Zhiquan Zhang,secretary of the municipal party committee of Baiyin City, Gansu Province, visited Biotecan headquarters to talk on investment, accompanied by Baiyin municipal government, Baiyin High-tech Zone Administrative Committee, Innovation Office and other departmental leaders. Dr. Lou, chairman of the Biotecan had a well-talk with them ...
A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stage
The rat has been used extensively as a model for evaluating chemical toxicities and for understanding drug mechanisms. However, its transcriptome across multiple organs, or developmental stages, has not yet been reported. Here we show, as part of the SEQC consortium efforts, a comprehensive rat transcriptomic BodyMap created by performing RNASeq on 320 samples from 11 organs of both sexes of juvenile, adolescent, adult and aged Fischer 344 rats. We catalogue the expression profiles of 40,064 genes, 65,167 transcripts, 31,909 alternatively spliced transcript variants and 2,367 non-coding genes/non-coding RNAs (ncRNAs) annotated in AceView. We find that organ-enriched, differentially expressed genes reflect the known organ-specific biological activities. A large number of transcripts show organ-specific, age-dependent or sex-specific differential expression patterns. We create a web-based, open-access rat BodyMap database of expression profiles with crosslinks to other widely used databases, anticipating that it will serve as a primary resource for biomedical research using the rat model.
Gastric cardia adenocarcinoma microRNA profiling in Chinese patients
Abstract Gastric cardia adenocarcinoma (GCA), which occurs at the gastroesophageal boundary, is one of the most malignant types of cancer. Over the past 30 years, the incidence of GCA has increased by approximately sevenfold, which has a more substantial increase than that of many other malignancies. However, as previous studies mainly focus on non-cardia gastric cancer, until now, the mechanisms behind GCA remain largely unknown. MicroRNAs (miRNAs) have been shown to play pivotal roles in carcinogenesis. To gain insight into the molecular mechanisms regulated by miRNAs in GCA development, we investigated miRNA expression
Clinicopathologicalsignificance of β-tubulin isotypeIII gene expression in breast cancer patients
Breast cancer is the most frequentlydiagnosed cancer in women in western countries, and it is the second most common cause of cancer-related deaths [1]. Despite recent improvements in the diagnosis and management of early disease, approximately 50% of women with breast cancer will develop distant metastases [2].
Sequencing study on familial lung squamous cancer
Lung cancer is the leading cause of cancer-related mortality worldwide. The majority of lung cancers are sporadic, and familial cases are extremely rare. Previous studies have mainly focused on sporadic lung cancer and identified a large quantity of driver genes. However, familial lung cancers are rarer and studied less. The present study recruited a Chinese family in which multiple members had developed lung squamous carcinoma. To find the causative mutations, whole exome sequencing was conducted using a peripheral blood sample of one lung squamous carcinoma patient, and certain variants were validated in more samples. Whole exome sequencing analysis obtained ~2.0 Gb of data (an average of 60x depth for each targeted base), and further validation experiments identified two functional variants in two cancer‑related genes (c.1218delA:p.E406fs in PDE4DIP and C1342A:p.L448I in CLTCL1). This study therefore provides useful sources for the further study of hereditary lung cancer.
Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylatio
The mechanisms underlying hypermethylation of tumor-suppressor gene promoters in cancer is not well understood. Here, we report that lysine acetylation of the oncogenic transcription factor STAT3 is elevated in tumors. We also show that genetically altering STAT3 at Lys685 reduces tumor growth, which is accompanied by demethylation and reactivation of several tumor-suppressor genes. Moreover, mutating STAT3 at Lys685 disrupts DNA methyltransferase 1–STAT3 interactions in cultured tumor cells and in tumors. These observations are confirmed by treatment with an acetylation inhibitor, resveratrol. Furthermore, reduction of acetylated STAT3 in triple-negative breast cancer cells leads to demethylation and activation of the estrogen receptor-α gene, sensitizing the tumor cells to antiestrogens. Our results also demonstrate a correlation between STAT3 acetylation and methylation of estrogen receptor-α in melanoma, which predicts melanoma progression. Taken together, these results suggest a role of STAT3 acetylation in regulating CpG island methylation, which may partially explain aberrant gene silencing in cancer. These findings also provide a rationale for targeting acetylated STAT3 for chemoprevention and cancer therapy.
CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with the Transcription Factor STAT3 in B Cells to Promote Cancer
How B cells affect cancer is uncertain. Yu and colleagues demonstrate that CD5 binds to IL-6 and induces STAT3 activation in the absence of IL-6Ra in B cells. In mouse tumor models, CD5+ but not CD5– B cells promote tumor growth, and this association was also observed in several types of human tumors.
TLR9 Is Critical for Glioma Stem Cell Maintenance and Targeting
Understanding supports for cancer stem–like cells in malignant glioma may suggest therapeutic strategies for their elimination. Here, we show that the Toll-like receptor TLR9 is elevated in glioma stem–like cells (GSC) in which it contributes to glioma growth. TLR9 overexpression is regulated by STAT3, which is required for GSC maintenance. Stimulation of TLR9 with a CpG ligand (CpG ODN) promoted GSC growth, whereas silencing TLR9 expression abrogated GSC development. CpG-ODN treatment induced Frizzled4-dependent activation of JAK2, thereby activating STAT3. Targeted delivery of siRNA into GSC was achieved via TLR9 using CpG–siRNA conjugates. Through local or systemic treatment, administration of CpG-Stat3 siRNA to silence STAT3 in vivo reduced GSC along with glioma growth. Our findings identify TLR9 as a functional marker for GSC and a target for the delivery of efficacious therapeutics for glioma treatment. Cancer Res; 74(18); 5218–28. 2014 AACR.
S1PR1-STAT3 Signaling Is Crucial for Myeloid Cell Colonization at Future Metastatic Sites
Recent studies underscore the importance of myeloid cells in rendering distant organs hospitable for disseminating tumor cells to colonize. However, what enables myeloid cells to have an apparently superior capacity to colonize distant organs is unclear. Here, we show that S1PR1-STAT3 upregulation in tumor cells induces factors that activate S1PR1-STAT3 in various cells in premetastatic sites, leading to premetastatic niche formation. Targeting either S1PR1 or STAT3 in myeloid cells disrupts existing premetastatic niches. S1PR1-STAT3 pathway enables myeloid cells to intravasate, prime the distant organ microenvironment and mediate sustained proliferation and survival of their own and other stromal cells at future metastatic sites. Analyzing tumor-free lymph nodes from cancer patients shows elevated myeloid infiltrates, STAT3 activity, and increased survival signal.
Infectious Diseases Testing
Respiratory Tract Infections Test
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Personalized Tumor Biomarker Testing
Genetic Analysis for Hereditary Tumor
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Cardiovascular Disease Testing
Genetic Testing
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Maternal and
Child
Health Testing
Non-Invasive
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Other Types of
Available Genetic
Testing
Drug Molecule
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Hereditary Disease
and Disease
Susceptibility
Testing
Genetic
Susceptibility Test
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Infectious
Diseases
Testing
Respiratory Tract Infections Test
. . .
see more
Personalized
Tumor Biomarker Testing
Genetic Analysis for Hereditary Tumor
. . .
see more
Cardiovascular Disease Testing
Genetic Testing
. . .
see more
Maternal and
Child
Health Testing
Non-Invasive
. . .
see more
Other Types
of Available
Genetic
Testing
Drug Molecule
. . .
see more
Hereditary
Disease
and Disease
Susceptibility
Testing
Susceptibility Test
. . .
see more
Circulating Tumor Cells (CTC), Tumour Exosome
Hereditary metabolic diseases Testing, Metabolism of Trace Element, Nutrition Material Metabolism, Drug Metabolism
Complete Genome Sequencing, Heredity Predisposing Genes, circulating tumor DNA, drug target genes, health risk genes
Low Density Lipoproteins, Tumor Protein Discriminant Analysis
Circulating Tumor Cells (CTC)
Tumour Exosome
Hereditary metabolic diseases Testing
Metabolism of Trace Element
Nutrition Material Metabolism
Drug Metabolism
Complete Genome Sequencing
Heredity Predisposing Genes
circulating tumor DNA, drug target genes
health risk genes
Low Density Lipoproteins
Tumor Protein Discriminant Analysis
(LDA)
RNA
DNA
tRNA
蛋白质组学
智能
医疗
云服务
电子病历数据库
临床
给药
系统
医学文献数据库
中医数据库
Omics Big Data Analysis System
intellegent Medical Cloud System
Clinical Drug Delivery System
RNA
DNA
tRNA
蛋白质组学
智能
医疗
云服务
电子病历数据库
临床
给药
系统
医学文献数据库
中医数据库
Omics Big Data
Analysis System
intellegent Medical Cloud System
Clinical Drug
Delivery System
First Shanghai Centre, 180 Zhangheng Rd., Pudong New District, Shanghai, China
First Shanghai Centre, 180 Zhangheng Rd., Pudong New District, Shanghai, China
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