To study the rat transcriptome at single-baseresolution, we constructed and sequenced 320 RNA-Seq librariesfrom 320 RNA samples derived from 16 female and 16 male rats from the Fischer 344 strain. Ten organs were evaluated per rat(adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen,
Abstract Gastric cardia adenocarcinoma (GCA), which occurs at the gastroesophageal boundary, is one of the most malignant types of cancer. Over the past 30 years, the incidence of GCA has increased by approximately sevenfold, which has a more substantial increase than that of many other malignancies. However, as previous studies mainly focus on non-cardia gastric cancer, until now, the mechanisms behind GCA remain largely unknown. MicroRNAs (miRNAs) have been shown to play pivotal roles in carcinogenesis. To gain insight into the molecular mechanisms regulated by miRNAs in GCA development, we investigated miRNA expression
Breast cancer is the most frequentlydiagnosed cancer in women in western countries, and it is the second most common cause of cancer-related deaths . Despite recent improvements in the diagnosis and management of early disease, approximately 50% of women with breast cancer will develop distant metastases .
Description of the pedigree. The lung cancer family were from Northwest China, Shaanxi province, and four members of the family were diagnosed with lung cancer (Fig. 1). The proband was a 65-year-old male who presented with a tumor in the inferior lobe of the right lung.
STAT3 Acetylation Affects Tumor Growth, DNA Methylation, and Tumor-Suppressor Gene Silencing. We first noticed strikingly in- creased STAT3 acetylation in melanoma tissues, compared with normal skin specimens (Fig. 1A). Similar immunohistochemical (IHC) analyses of human colon cancer tissues also showed that STAT3 acetylation was elevated in malignant areas compared
How B cells affect cancer is uncertain. Yu and colleagues demonstrate that CD5 binds to IL-6 and induces STAT3 activation in the absence of IL-6Ra in B cells. In mouse tumor models, CD5+ but not CD5– B cells promote tumor growth, and this association was also observed in several types of human tumors.