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Research papers album of Shanghai Zhangjiang medical research and development transformation center

Biotecan achieved a great-leap-forward development in the field of precision medicine. During the construction of the international advanced technology center for the precision medical applications, the international clinical medical laboratory, we created Zhangjiang Innovation Demonstration Zone Precision Medical data center, based on the precision medical master studio and precision medical application network. We have established cooperation with the State Key Laboratory of Molecular Tumor of Chinese Academy of Medical Sciences, Fudan University and the Second Military Medical University , and approved the major projects of the Ministry of Science and Technology, 863 Project "Research on Key Technology of Biological Data Application", and "Shanghai Zhangjiang National Innovation Demonstration Zone public service platform of Precision Medical data " and " Shanghai precision medical data center "and so on. Under the government leading, we have established overseas technology parks. 18 research results with our partners have been published in Nature, Nat Biotechnol, Cancer Res, Nat Commun, Proc Natl Acad Sci USA, Cancer Cell and Immunity, with the cumulative impact factor of 190.97, the highest impact factor of 41.514.

The above article directory (SCI record )

  • Gao Y, Zhu Y, Zhang Z, Zhang C, Huang X, Yuan Z. Clinical significance of pancreatic circulating tumor cells using combined negative enrichment and immunostaining-fluorescence in situ hybridization. J Exp Clin Cancer Res. 2016 Apr 12;35(1):66. IF=4.429
  • Gao S, Zhou F, Zhao C, Ma Z, Jia R, Liang S, Zhang M, Zhu X, Zhang P, Wang L, Su F, Zhao J, Liu G, Peng B, Feng X. Gastric cardia adenocarcinoma microRNA profiling in Chinese patients. Tumour Biol. 2016 Jan 18. IF=3.611
  • Yuan Sheng, Ting Wang, Hengyu Li, Zhenzhen Zhang, Jianghao Chen, Chenyang He, Yongping Li, Yonggang Lv, Juliang Zhang, Cheng Xu, Zhen Wan, Chen Huang and Ling Wang. Comparison of analytic performances of Cellsearch and iFISH approach in detecting cirtulating tumor cells. Oncotarget. 2015. Dec. 19; 6: DOI: 10.18632/oncotarget.6688. IF=6.359
  • He Q, Peng B, Zhuang D, Xiao L, Zheng L, Fan Z, Zhu J, Xu B, Xu C, Zhao J, Wu L, Zhou P, Hou L, Yu F, Zhao G. Clinicopathological significance of β -tubulin isotype III gene expression in breast cancer patients. Cancer Biomark. 2015 Nov 24;15(6):823-31. doi: 10.3233/CBM-150526. IF=1.721
  • Peifer M, Hertwig F, Roels F, Dreidax D, Gartlgruber M, Menon R, Krämer A, Roncaioli JL, Sand F, Heuckmann JM, Ikram F, Schmidt R, Ackermann S, Engesser A, Kahlert Y, Vogel W, Altmüller J, Nürnberg P, Thierry-Mieg J, Thierry-Mieg D, Mariappan A, Heynck S, Mariotti E, Henrich KO, Gloeckner C, Bosco G, Leuschner I, Schweiger MR, Savelyeva L, Watkins SC, Shao C, Bell E, Höfer T, Achter V, Lang U, Theissen J, Volland R, Saadati M, Eggert A, de Wilde B, Berthold F, Peng Z, Zhao C, Shi L, Ortmann M, Büttner R, Perner S, Hero B, Schramm A, Schulte JH, Herrmann C, O'Sullivan RJ, Westermann F, Thomas RK, Fischer M. Telomerase activation by genomic rearrangements in high-risk neuroblastoma. Nature. 2015 Oct 29;526(7575):700-4. doi: 10.1038/nature14980. Epub 2015 Oct 14. IF=41.456
  • Li S, Wang L, Ma Z, Ma Y, Zhao J, Peng BO, Qiao Z. Sequencing study on familial lung squamous cancer. Oncol Lett. 2015 Oct;10(4):2634-2638. Epub 2015 Aug 7. IF=1.554
  • Lu J, Yin J, Dong R, Yang T, Yuan L, Zang L, Xu C, Peng B, Zhao J, Du X. Targeted sequencing of cancer-associated genes in hepatocellular carcinoma using next generation sequencing. Mol Med Rep. 2015 Sep;12(3):4678-82. doi: 10.3892/mmr. 2015.3952. Epub 2015 Jun 17. IF=1.554
  • Lu M, Li J, Luo Z, Zhang S, Xue S, Wang K, Shi Y, Zhang C, Chen H, Li Z. Roles of dopamine receptors and their antagonist thioridazine in hepatoma metastasis. Onco Targets Ther. 2015 Jun 22;8:1543-52. doi: 10.2147/OTT.S77373. eCollection 2015. IF=2.311
  • Xiao X, Wang W, Zhang H, Gao P, Fan B, Huang C, Fu J, Chen G, Shi L, Zhu H, Li X, Li J, Fan H, Wu Z, Guo Z, Hu Y, Wu S, Yu X, Xu C, Wang Z. Individualized chemotherapy for osteosarcoma and identification of gene mutations in osteosarcoma. Tumour Biol. 2015 Apr; 36(4):2427-35. doi: 10.1007/s13277-014-2853-5. Epub 2014 Nov 28. IF=3.611
  1. SEQC/MAQC-III Consortium. A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium. Nat Biotechnol. 2014 Sep; 32(9):903-14. doi: 10.1038/nbt.2957. Epub 2014 Aug 24. IF=41.514
  2. Herrmann A, Cherryholmes G, Schroeder A, Phallen J, Alizadeh D, Xin H, Wang T, Lee H, Lahtz C, Swiderski P, Armstrong B, Kowolik C, Gallia GL, Lim M, Brown C, Badie B, Forman S, Kortylewski M, Jove R, Yu H. TLR9 is critical for glioma stem cell maintenance and targeting. Cancer Res. 2014 Sep 15;74(18):5218-28. doi: 10.1158/0008-5472.CAN-14-1151. Epub 2014 Jul 21. IF=9.329
  3. Yu Y, Fuscoe JC, Zhao C, Guo C, Jia M, Qing T, Bannon DI, Lancashire L, Bao W, Du T, Luo H, Su Z, Jones WD, Moland CL, Branham WS, Qian F, Ning B, Li Y, Hong H, Guo L, Mei N, Shi T, Wang KY, Wolfinger RD, Nikolsky Y, Walker SJ, Duerksen-Hughes P, Mason CE, Tong W, Thierry-Mieg J, Thierry-Mieg D, Shi L, Wang C. A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages. Nat Commun. 2014;5:3230. doi: 10.1038/ncomms4230. IF=11.47
  4. Lee H, Zhang P, Herrmann A, Yang C, Xin H, Wang Z, Hoon DS, Forman SJ, Jove R, Riggs AD, Yu H. Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation. Proc Natl Acad Sci U S A. 2012 May 15;109(20):7765-9. doi: 10.1073/pnas.1205132109. Epub 2012 Apr 30. IF=9.674
  5. Deng J, Liu Y, Lee H, Herrmann A, Zhang W, Zhang C, Shen S, Priceman SJ, Kujawski M, Pal SK, Raubitschek A, Hoon DS, Forman S, Figlin RA, Liu J, Jove R, Yu H. S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites. Cancer Cell. 2012 May 15;21(5):642-54. doi: 10.1016/j.ccr.2012.03.039. IF=23.523
  6. Gongping Wang, Zhenzhen Wang, Bo Zhou, Canhui Jin, Zengfang Wang, Yantong Yang, Wei Zhang, Ye Chen, Bianhong Li, Lin Guo, Deping Han, Bo Peng, Jiangman Zhao, Chang Zhang, Xiaoshan Feng , Lu Wang. Targeted deep sequencing reveals recurrent mutations in gastric carcinomas. Accepted by Oncology Letters. IF=1.554
  7. Chunyan Zhang, Hong Xin,Wang Zhang, et al. CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with the Transcription Factor STAT3 in B Cells to Promote Cancer. Immunity. 2016 Apr 19;44(4):913-23. doi: 10.1016/j.immuni .2016.04.003. IF=24.082
  8. He Q, Peng B, Zhuang D, Xiao L, et al. Clinicopathological significance of β -tubulin isotype III gene expression in breast cancer patients. Cancer Biomark. 2015;15(6):823-31. doi: 10.3233/CBM-150526. IF=1.736
  9. Chaoqian Liu, Yan Guo, Weiwei Wu, Zhenzhen Zhang, Lu Xu, Kainan Wu, Wei Hu, Guoping Liu, Junyi Shi, Cheng Xu, Jianwei Bi, Yuan Sheng. The plasma olfactomedin 4 level in peripheral blood and its association with clinical features of breast cancer. Accepted by Oncology Letters. IF=1.482
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